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KMID : 0880220180560040238
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Journal of Microbiology
2018 Volume.56 No. 4 p.238 ~ p.245
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Hydrogen sulfide inhibits the growth of Escherichia coli through oxidative damage
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Fu Liu-Hui
Wei Zeng-Zheng
Hu Kang-Di
Hu Lan-Ying
Li Yan-Hong
Chen Xiao-Yan
Han Zhuo
Yao Gai-Fang
Zhang Hua
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Abstract
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Many studies have shown that hydrogen sulfide (H2S) is both detrimental and beneficial to animals and plants, whereas its effect on bacteria is not fully understood. Here, we report that H2S, released by sodium hydrosulfide (NaHS), significantly inhibits the growth of Escherichia coli in a dose-dependent manner. Further studies have shown that H2S treatment stimulates the production of reactive oxygen species (ROS) and decreases glutathione (GSH) levels in E. coli, resulting in lipid peroxidation and DNA damage. H2S also inhibits the antioxidative enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) and induces the response of the SoxRS and OxyR regulons in E. coli. Moreover, pretreatment with the antioxidant ascorbic acid (AsA) could effectively prevent H2S-induced toxicity in E. coli. Taken together, our results indicate that H2S exhibits an antibacterial effect on E. coli through oxidative damage and suggest a possible application for H2S in water and food processing.
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KEYWORD
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hydrogen sulfide, Escherichia coli, oxidative stress, DNA damage, antioxidative enzyme
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